CASP3 and schwannoma: Of note, the overexpression of miRNA 344a-3p by using the mimic combined with curcumin treatment in RT4 cells activated the expression of apoptotic markers, such as caspase-3, and caspase-9 compared to the control, suggesting that miRNA344a-3p plays an important role in curcumin-induced apoptosis in RT4 schwannoma cells.