C9orf72 and amyotrophic lateral sclerosis: The same notion is strengthened by the observation that ANG, where four mutations in the coding region of the gene were identified in 298 ALS patients [8], is involved in processing of RNAs and that C9orf72 repeats forms RNA foci in the nucleus of the cells in particular in neuron, and sequester key RBPs leading to impairment in RNA processing events [9,10].