TARDBP and amyotrophic lateral sclerosis: In fact, even if SOD1, TDP-43 and FUS/TLS are commonly involved in ALS through different pathways, their common implication in gene expression/RNA homeostasis suggests that alterations of expression regulation may represent key events in ALS pathogenesis [[15], [16], [17]], supporting also by the important involvement of numerous RBP in ALS.