The complexity of ALS disease is due to the numerous different cellular features, one of those are the “paraspeckles”, nuclear bodies formed by a set of specialized proteins and RNAs, such as the lncRNA Nuclear-Enriched Abundant Transcript 1_2 (NEAT1_2T) [30], that was identified associated to ALS in brain [31]. Here, NEAT1 is linked to amyotrophic lateral sclerosis.