GRN and frontotemporal dementia: Between 20 and 50% of frontotemporal dementia (FTD) cases are familial [34] and characterised by mutations in microtubule-associated tau protein, granulin, valosin-containing protein, chromatin-modifying 2B, TARDNA binding protein 43 encoding gene, integral membrane protein 2B and tank-binding kinase 1 resulting in impairment in language, behaviour, memory and motor function [[35], [36], [37]].