Cleavage of APP by β-site APP-cleavage enzyme 1 (BACE1) generates soluble APPβ (sAPPβ) and the fragment C99 which is then subsequently cleaved by the γ-secretase enzyme complex to produce the insoluble Aβ42 peptide; the main constituent of extracellular plaques found in the brain of AD individuals [9,10]. Here, APP is linked to Alzheimer disease.