IFNA1 and neoplasm: Ab could kill some tumor cells through ADCC by macrophages that produce type I IFNs for cross-priming; IFN binds to interferon α/β receptor (IFNAR) and activates Dendritic Cells (DCs) to better process tumor antigens for cross-priming T cells in the DLN; tumor-specific CTLs travel back to the tumor site for tumor control.