NFE2L2 and type 2 diabetes mellitus: A recent study [21] showed that Th1/Th2 ratio and levels of cytokines (e.g., IL-4, IL-10, IL-13, and IFN-γ) were significantly elevated, whereas nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream targets, which act with antioxidant, detoxification, and maintenance of cellular redox homeostasis and glutathione homeostasis and influence mitochondrial biogenesis, were decreased in T2DM patients.