Indeed, CRP values were positively associated with pregnancy adverse outcomes both in the univariate (β=0.043, 95% CI 0.003-0.083, p=0.036) and in the multivariate model when maternal age, hypertension, and development of GDM were considered (β=0.05, 95% CI 0.010-0.090, p=0.015, Table 4). This evidence concerns the gene CRP and gestational diabetes.