These inhibitors have generally an acceptable safety profile, with common side effects including nausea, vomiting, diarrhea, and hyperglycemia. Inhibitors of PI3K or Akt seem to be more effective than mTOR inhibitors; this fact may be due to the incomplete inhibition of the pathway by the latter. Unfortunately, these inhibitors have not met expectations as a monotherapy. The gene discussed is AKT1; the disease is Hyperglycemia.