Among the 10 hub genes, the following four genes were found to be associated with the prognosis of bladder cancer patients: ACTA2 (P = 0.0472), CCNB1 (P = 0.00354), CDC20 (P = 0.0334) and VEGFA (P = 0.00684). The gene discussed is VEGFA; the disease is urinary bladder carcinoma.