In 2013, Thanassoulis and colleagues performed genome-wide screening on 6942 patients diagnosed with aortic valve calcification based on computed tomography (CT) scans, and identified an SNP (rs10455872) in the LPA gene in chromosome 6 that was significantly correlated with aortic valve stenosis (Thanassoulis et al. The gene discussed is LPA; the disease is aortic valve stenosis.