TFF2 and pancreatic neoplasm: 2016); the expression of TFF2 in PDAC was reduced compared to that of normal tissues, and transgene overexpression suppressed the proliferation of pancreatic cancer cell lines. The study revealed that TFF2 is expressed in pancreatic cancer cell lines while the expression appears to be epigenetically regulated; the TFF2 promoter was hypermethylation in TFF-2 low-expressing Panc-1 cells but not in TFF2 high-expressing AsPC-1 cells. Our data from 13 pancreatic cell lines reveal that a majority of them expressed TFF2 transcript and secreted significant amounts of TFF2.