[1–8] However, TNF-α blocking agents are very expensive and currently constitute the majority of the costs of IBD therapy.[9] IFX-biosimilars, such as CT-P13 (Inflectra/ Remsima),Celltrion) and Flixabi (Biogen) are available now.[10–13] These biosimilars are expected to have the same specificity and the same sequence as the original molecule IFX (Remicade), but are marketed at a much lower price than the first-generation anti-TNF-α blocking agents, which will make treatment of these diseases more cost-effective. The gene discussed is TNF; the disease is inflammatory bowel disease.