Both inhibitors, DP-460 and SB-3CT, cross the BBB and have been shown to exert beneficial effects in neurological diseases, including acute stroke and amyotrophic lateral sclerosis, but have not been tested in a model of VCID.[10, 11] We used SHRSP fed a high salt, low protein JPD to test the effect of the two drugs on white matter injury with MRI and behavior with the Morris Water Maze (MWM).[12, 13] We hypothesized that MMP-9 inhibition was the reason for the beneficial effects of minocycline. The gene discussed is MMP9; the disease is nervous system disorder.