In detail, it has been recently shown that LO shed by PCa cell line LnCapMyrAKT1, harboring AKT1 kinase activity, were internalized by human normal prostate fibroblasts, inducing their reprogramming through the activation of stromal Myc [66], a proto-oncogene implicated in cancer initiation, maintenance, and stemness in different models [67, 68]. The gene discussed is MYC; the disease is cancer.