In addition, also CSCs remodeled their specific niche by educating monocytes/macrophages towards tumor-associated macrophages (TAMs), and the CSC-educated TAMs reciprocally promoted the stem-like properties of CSCs as well as progression and ADT resistance of prostate cancer via interleukin 6 (IL6)/STAT3 [73]. The gene discussed is IL6; the disease is Familial prostate cancer.