In the present study, differential expression was observed for 12 genes in OSCC compared to adjacent non-tumor tissues. CYP27A1, CYP2E1, CYP2R1, CYP2J2, CYP2U1, CYP4F12, CYP4X1, CYP4B1, PTGIS or CYP8A1, ALOX12, and MAOB genes presented reduced expression, while the CYP27B1 gene showed increased expression in OSCC. This evidence concerns the gene CYP27A1 and neoplasm.