CYP2R1 and neoplasm: In the present study, differential expression was observed for 12 genes in OSCC compared to adjacent non-tumor tissues. CYP27A1, CYP2E1, CYP2R1, CYP2J2, CYP2U1, CYP4F12, CYP4X1, CYP4B1, PTGIS or CYP8A1, ALOX12, and MAOB genes presented reduced expression, while the CYP27B1 gene showed increased expression in OSCC.