In the present study, differential expression was observed for 12 genes in OSCC compared to adjacent non-tumor tissues. CYP27A1, CYP2E1, CYP2R1, CYP2J2, CYP2U1, CYP4F12, CYP4X1, CYP4B1, PTGIS or CYP8A1, ALOX12, and MAOB genes presented reduced expression, while the CYP27B1 gene showed increased expression in OSCC. The gene discussed is CYP27B1; the disease is neoplasm.