The results of protein analysis by ELISA showed that expression of ALOX12 (median: OSCC = 12.09 ng/μL vs. non-tumor = 15.80 ng/μL), CYP2E1 (median: OSCC = 0.046 ng/μL vs. non-tumor = 0.053 ng/μL), CYP2J2 (median: OSCC = 21.91 ng/μL vs. non-tumor = 21.34 ng/μL), and CYP2U1 (mean: OSCC = 11.95 ng/μL vs. non-tumor = 14.57 ng/μL) proteins were not statistically different between OSCC and non-tumor tissues (p > 0.05), although the lower expression was observed in tumors. This evidence concerns the gene ALOX12 and neoplasm.