Regarding clinical and histopathological parameters of tumor we did not find statistical significance between reduced expression of CYP27A1, CYP2E1, CYP2R1, CYP2J2, CYPU1, CYP4F12, CYP4X1, CYP4B1, PTGIS, ALOX12, and MAOB genes and increased expression of CYP27B1 gene with tumor extension, nodal metastasis, and tumor progression in OSCC development. The gene discussed is CYP2R1; the disease is neoplasm.