EIF4E and depressive disorder: Amorim et al. (2018) propose that eIF4E phosphorylation may control inflammatory responses in depression by regulating binding of the 3′ UTR element (GAIT) onto the 5′ eIF4F complex in circularized pro-inflammatory mRNAs. The GAIT complex acts as a translational repression mechanism that controls the translation of pro-inflammatory mRNAs (Mukhopadhyay et al., 2009).