MASP-2 is produced in hepatocytes, and its promoter is regulated by cytokines such as interleukin (IL)-1b and IL-6 or transcription factor STAT3 (15).It is possible that tumor tissue releases mediators that may increase serum levels of MASP-2, however this is a hypothesis that needs to be clarified. The gene discussed is STAT3; the disease is neoplasm.