TNF and inflammatory bowel disease: In that sense they could provide more specific therapeutic means than generic immunosuppressants (e.g., corticosteroids, aminosalicylates, methotrexate, cyclosporine, azathioprine, and mercaptopurine) or more effective than single cytokine inhibitors (e.g., anti-TNF, anti-IL12/23 or NSAIDs for Cox-2) currently used to treat patients suffering from, for example, IBD.