To assess whether HIV captured by cervical myeloid cells is infectious, we co-cultured sorted myeloid cells, CD4 T cells and CD8 T cells from 5 HIV-infected normal human donor cervical explants, harvested 20 h post-infection, with heterologous HIV-susceptible activated blood CD4 T cells, using a sensitive assay developed to detect latent HIV infection in human blood cells (29). The gene discussed is CD4; the disease is infection.