Purified CD14+ monocytes from MDD patients expressed significantly lower mRNA levels of GR [T(34) = 2.49; p = 0.018; Hedges' g = 0.21] as well as its downstream target GILZ [T(34) = 2.08; p = 0.045; Hedges' g = 0.39] (Figure 2A). Here, NR3C1 is linked to major depressive disorder.