AICDA and common variable immunodeficiency: To investigate if there are CVID patients in our cohort with a defect in the molecular mechanism of SHM we analyzed the percentage of mutations in AID (RGYW/WRCY) and pol eta (WA/TW) motifs (Figures 2A–C), the percentage of mutations at GC location (Figure 2D), and the percentage of transition mutations at GC (Figure 2E) or A/T locations (Figure 2F).