After adjusting for sex, age, BMI, fasting plasma glucose, HbA1c, ALT, HDL cholesterol, eGFR, and statin use, IFG or type 2 diabetes was independently associated with serum netrin-1 levels (standardized [STD] β = 0.405, P < 0.001; Model 2). This evidence concerns the gene NTN1 and type 2 diabetes mellitus.