High fat diet-fed obese mice showed higher expression of netrin-1 and UNC5B mRNA and macrophage retention in visceral adipose tissue compared to lean chow-fed mice, and deletion of hematopoietic netrin-1 facilitated adipose tissue macrophage emigration, reduced inflammation, and improved insulin resistance in obese mice (40). The gene discussed is NTN1; the disease is Insulin resistance.