Genetic variants of the triggering receptor expressed on myeloid cells-2 (TREM2), which is dominantly expressed in microglia in central nervous system (CNS), result in increased risk of developing late-onset AD (LOAD) and other neurodegenerative disorders (Guerreiro et al., 2013; Jonsson et al., 2013; Painter et al., 2015; Ulrich and Holtzman, 2016). The gene discussed is TREM2; the disease is Alzheimer disease.