TREM2 and Nasu-Hakola disease: Molecules associated with these “microgliopathies” mainly include the 12 kDa DNAX activating protein (DAP12) and TREM2 in Nasu-Hakola disease (NHD; Paloneva et al., 2000, 2002); and the colony stimulating factor 1 receptor (CSF1R) in hereditary diffuse leukoencephalopathy with spheroids (HDSL; Rademakers et al., 2011).