Recycling of TREM2 in microglia is regulated by Beclin-1, a protein involved in autophagy (Salminen et al., 2013) and levels of TREM2 are reduced in AD brain microglia (Lucin et al., 2013), implying a potential link between TREM2 and autophagy. The gene discussed is TREM2; the disease is Alzheimer disease.