PTX3 and shigellosis: In conclusion, at a local level of Shigella infection, PTX3 could tip the balance toward bacterial eradication playing a double role: on the bacterial side, it helps to reduce epithelial cell invasion, to implement macrophage phagocytosis and to favor complement activity; on the host tissue side, it contributes to the prevention of the development of the destructive inflammation, which is a main feature of shigellosis.