For patients with an intestinal type of cancer, 5-year survival reached 64.1% (95% CI 58.2–70.0) among those with a low serum MMP-14 and 13.3% (95% CI 1.0–25.6; p = 0.002; Fig 2C) among patients with a high serum MMP-14. The gene discussed is MMP14; the disease is cancer.