MYC and neoplasm: Therefore, unless glutamine-addicted tumor cells utilize oxygen at a similar efficiency as Warburg tumor cells, for example by adopting a metabolic phenotype with higher Warburg Number than Warburg tumor cells (e.g., being MYC-positive may allow tumor cells to have even higher glycolytic rate [60]), the experimentally observed glutamine addiction in diverse tumor cell types cannot be explained by its role in supplying carbon to the TCA cycle.