TTBK2 and spinocerebellar ataxia type 11: While we can’t yet exclude the emergence of more subtle defects occurring at advanced age, it does not appear one allele of Ttbk2sca11 is sufficient to cause phenotypes recapitulating human SCA11 in the presence of a second WT allele of Ttbk2, (ie Ttbk2sca11/+) in mice.