TRIML2 and infection: In the permissive cells Mrc5 and Vero with primary infection of HCMV and HSV1, respectively, we observed that the protein level of STAT6 was gradually inhibited along with the increase expression of lytic genes (IE1/2 in HCMV, ICP0 in HSV1), while ubiquitylated TRIML2 was enhanced (Fig 8B and 8C).