To further investigate whether the enhanced Th1 response by LTα1β2-LTβR signaling deficiency is restricted to a specific viral infection, mice were immunized using OVA combined with CpG oligodeoxynucleotides (CpG-1826, a TLR9 agonist) as adjuvant (OVA-CpG). The gene discussed is LTBR; the disease is viral infectious disease.