STX1B and epilepsy: Interestingly, although the association signal for STX1B was only significant in the JME analysis, rare pathogenic variants in STX1B have been recently found in a spectrum of epilepsies, including genetic epilepsy with febrile seizures plus (GEFS+), genetic generalized epilepsies (including JME), epileptic encephalopathies and even some focal epilepsies49,50 (Wolking et al., Manuscript submitted (2018).