PNPO and genetic generalized epilepsy: These prioritized genes include seven ion-channel genes (SCN1A, SCN2A, SCN3A, GABRA2, KCNN2, KCNAB1, and GRIK1), three transcription factors (ZEB2, STAT4 and BCL11A), the histone modification gene BRD7, the synaptic transmission gene STX1B and the pyridoxine metabolism gene PNPO. Notably, a conditional transcriptome-wide association study (TWAS) analysis suggests that the signal for genetic generalized epilepsy at 17q21.32, which was also observed in an earlier study12, seems driven by regulation of expression of PNPO (Supplementary Fig. 8).