FLNC and restrictive cardiomyopathy: Variants predicted to lead to premature termination of translation in FLNC have been detected in individuals with dilated, arrhythmogenic, and restrictive cardiomyopathies,17–20 although this class of variant has not been widely reported in HCM patient cohorts17,21,22 (ACMG criteria PVS1_Strong10,14).