Although TERT promoter mutations were rare in CCN-HCC (9 vs. 55% in others, P = 2.4 × 10−5), TERT promoter rearrangements were highly enriched (82 vs. 7%, P = 1.8 × 10−15, Fig. 5e) and involved regions of active chromatin in normal liver, in the vicinity of highly expressed liver enzymes (ALB, FGG, SEP15, SLC12A7 and BAAT) or transcription factors (HNF4A, CEBPA, and CEBPB) (Supplementary Data 8, Supplementary Fig. 10). This evidence concerns the gene CEBPB and hepatocellular carcinoma.