We also identified one tumor with HBV insertion and 3 tumors with AAV2 insertions in CCNA2. Finally, 6 tumors strongly overexpressed CCNA2 (FPKM > 15), 3 of which displayed 23–48 Mb intra-chromosomal deletions linking the intergenic region downstream CCNA2 with the highly expressed ALB, AFP, and ADH6 genes (Supplementary Fig. 2). Here, ADH6 is linked to neoplasm.