CCNA2 and hepatocellular carcinoma: To identify the exhaustive landscape of CCNA2 and CCNE1 alterations in HCC, we analyzed 751 HCC comprising an in-house series of 160 tumors (LICA-FR) analyzed by RNA sequencing (RNAseq, n = 160), whole exome (WES, n = 156) and whole genome sequencing (WGS, n = 45) (Supplementary Data 1), the TCGA17 series (334 HCC with RNA-seq and WES, 48 or which also analyzed by WGS) and the ICGC-JP11 series (257 HCC with WGS data, Supplementary Data 2).