CCNA2 and hepatocellular carcinoma: In total, we identified 10 HCC with CCNA2 activation events in the LICA-FR series (6.2%), 2 in the ICGC-JP series (0.8%) and 18 in the TCGA series (5.4%), associated with a significant increase of CCNA2 mRNA expression, but also generating a truncated cyclin A2 protein lacking the N-terminal destruction box and the ubiquitination site.