In the TCGA series, we identified 7 CCNA2 fusions with 5 different partner genes (FAM160A1, KIAA1109 × 3, LIPC, UBA6 and TDO2, Fig. 1a, d), all of which involved the first untranslated exon(s) of the partner gene linked with exons 3–8 of CCNA2. WGS revealed in another tumor a focal deletion starting in the 5′ UTR region and ending in CCNA2 intron 2 (Supplementary Fig. 2). Here, TDO2 is linked to neoplasm.