PCDHA8 and male reproductive organ cancer: To determine pathophysiological role of the circAMOTL1L-miR-193a-5p-Pcdha8 pathway in prostate tumorigenesis, we established PCa xenograft models by implanting PC3 cells stably overexpressing circAMOTL1L, anti-miR-193a-5p (miR-193a-5p inhibitor), or both into nude mice.