Further, we detected the circAMOTL1L and RBM25 expression in human PCa tissues by using in situ hybridization of circAMOTL1L probe combined with immunostaining with the anti-RBM25 antibody and found that circAMOTL1L and RBM25 were mainly co-localized in the same cells (Supplementary Fig. 9c). Here, RBM25 is linked to posterior cortical atrophy.