Although some research has revealed that clustered Pcdhs are mainly expressed in nervous system and play critical roles in neurodevelopment [8, 9], a member of this superfamily, PCDHGC3, is also highly expressed in normal colonic epithelium, while its expression is suppressed in carcinoma cell lines [10], and PCDH10 is also downregulated in gastric cancer cell lines [11], suggesting that Pcdhs may act as tumor suppressors through influencing tumor growth and metastasis. The gene discussed is PCDHGC3; the disease is neoplasm.