Various mechanisms have been proposed in which salinomycin exerted its anti-cancer effects such as an autophagic cell death inducer16; signal transducer and activator of transcription 3 (STAT3), or Wnt signaling pathway inhibitor17; ATP-binding cassette (ABC) transporter inhibitor16,18; potent mitochondrial function inhibitor16,19–22. This evidence concerns the gene STAT3 and cancer.