KDM3A and persistent truncus arteriosus: To test if JIB-04 targets KDM3A in TAC-induced pathological hypertrophic remodeling in vivo, we treated sham and TAC WT and Kdm3a-Tg mice with JIB-04 or vehicle (administered by gavage) (Fig. 6a) at a dose with no overt toxicity22.