NPPB and persistent truncus arteriosus: Six weeks after TAC, KO hearts were significantly smaller than controls (Fig. 3a), with a lower HW/BW ratio (Fig. 3b), smaller cardiomyocytes (Fig. 3c), less fibrosis (Fig. 3d, Supplementary Fig. 3a), improved cardiac function (Fig. 3e–g), and reduced expression of Nppa, Nppb, and Myh7 (Fig. 3h).