The association between region of origin, transmission risk group, HIV RNA, smoking status, and HCV and CMV coinfection at the start of ART and CD4 and CD8 cell count and ratio trajectories and levels reached at 8 years is discussed in text and shown in figures (see Figures SDC 13–15, Supplemental Digital Content, http://links.lww.com/QAI/B244 and Table SDC 16, Supplemental Digital Content, http://links.lww.com/QAI/B244). The gene discussed is CD8A; the disease is coinfection.