Inhibition of liver-derived AGT synthesis leading to reduced blood pressure was also demonstrated by a study with a single intracardiac injection of adeno-associated virus encoding full-length rat AGT to 5-day-old SHR, which reduced AGT expression in liver, delayed the onset of hypertension and decreased blood pressure for up to 6 months in adult SHR [35]. The gene discussed is AGT; the disease is Hypertension.