PPARGC1A and cardiac hypertrophy: Cardiac hypertrophy and a metabolic switch from fatty acid to glucose utilization are hallmarks of an adaptive response to chronic stress (Hansson et al, 2004; Ventura‐Clapier et al, 2011; Tuomainen & Tavi, 2017), reflected in the GRAC mice by depletion of glycolytic intermediates, downregulation of PPAR‐α, and the upregulation of ATF4 (Quiros et al, 2017), PGC‐1α, and TFAM.