Cardiac hypertrophy and a metabolic switch from fatty acid to glucose utilization are hallmarks of an adaptive response to chronic stress (Hansson et al, 2004; Ventura‐Clapier et al, 2011; Tuomainen & Tavi, 2017), reflected in the GRAC mice by depletion of glycolytic intermediates, downregulation of PPAR‐α, and the upregulation of ATF4 (Quiros et al, 2017), PGC‐1α, and TFAM. Here, ATF4 is linked to cardiac hypertrophy.