Moreover, they also found that if MT-ND5 contains a single nucleotide polymorphism (m.13708G > A), which is characteristic for mitochondrial haplogroup J and is linked to a synergistic and deleterious interaction with a mtDNA disease known as Leber's hereditary optic neuropathy (LHON), the formation of m1A in MT-ND5:1374 is reduced. The gene discussed is MCAT; the disease is Leber hereditary optic neuropathy.