Many RNFs, like RNF8 and RNF168, have an important role in the DDR and are tightly modulated by other RNFs (e.g., RNF169 [22], [23], [24]) and scaffold proteins, e.g., histone H1 [18], B-cell lymphoma/leukemia 10 (BCL10) [25], and lethal (3) malignant brain tumor-like 2 (L3MBTL2) [26]). The gene discussed is BCL10; the disease is brain cancer.