VEGFA and age-related macular degeneration: In addition, in a separate study a 12-month evaluation of retinal function by electroretinography (ERG) in human AMD patients treated with IVT injections of ranibizumab did not reveal any functional decline,48 and retinal or retina pigmented epithelium atrophy and other serious ocular adverse events have not been observed in clinical trials of other gene-based approaches to VEGFA inhibition at 12 months.14, 15, 37