CASP3 and brain infarction: Publication bias Funnel plots for all primary and secondary outcomes are shown in Supplemental Figure S1. Where results on more than 10 studies were reported there was evidence of significant reporting bias (Egger's test, p < 0.05) for brain infarct size, heart dP/dT, kidney BUN, kidney Creatinine, IL-1B, IL-6, TNFa, Bcl-2, Caspase-3 and HSP-70.