Over-activation by reducing glutamate reuptake through EAAT2 antagonism (DHK) is of particular relevance to depression, since EAAT2 shows reduced expression levels in postmortem cerebral tissue samples of individuals who suffered from depression (Choudary et al., 2005, Miguel-Hidalgo et al., 2010) and in animal models of depression (Zink et al., 2010). This evidence concerns the gene SLC1A2 and depressive symptom measurement.