This finding corroborates a previous reportdescribing a rare genetic variant in SOX17 associated with heritablepulmonary arterial hypertension.4 Thepresent study posits that common variation in SOX17 expression is adeterminant of pulmonary arterial hypertension and is present more often in patientswith pulmonary arterial hypertension than are other rare genetic variants. Here, SOX17 is linked to pulmonary arterial hypertension.