We note, however, that previous studies revealed at most minor differences in tumour aggressiveness between carriers and noncarriers of HOXB13 G84E mutation [5], [6], [7], [8], [9], [10], [11], [12], [14], [16], [20], [21] and that familial RRs of PCa estimated on the basis of the UKGPCS population-based arm were in line with the estimates from other large epidemiological studies [40]. Here, HOXB13 is linked to neoplasm.