HOXB13 and posterior cortical atrophy: It is therefore crucial to have precise risk estimates for the known PCa susceptibility variants, including mutations in HOXB13. We have performed a systematic review of published risk estimates for HOXB13 G84E mutation carriers, and using the largest PCa case-family dataset available to date, we have estimated age-specific PCa risks for mutation carriers and investigated variation in these risks by PCa family history.