SDC1 and cancer: In addition to the loss of contact with extracellular matrix, the various expression patterns (reduced, shed, or subcellular) of SDC1 in many malignant cancer cells might suggest that this could be one of their acquired properties; by losing the expression of SDC1 on their cell surface, they will become refractory to the microorganism/LPS triggering non-canonical inflammasome pathway, thus avoiding their own death.