Inoculation of DS9 and DS10 lysates into a mouse model of tauopathy (PS19) that is based on expression of 1N4R human tau with a single disease-associated mutation (P301S) (Yoshiyama et al., 2007), created distinct neuropathological phenotypes. These could be transmitted stably across multiple generations of mice, and finally back into the RD-YFP biosensor cells, where DS9 and DS10 strains displayed their original morphology (Sanders et al., 2014). This evidence concerns the gene MAPT and tauopathy.