BCOR and central nervous system neoplasm: BCOR and its paralogue BCORL1 have been associated with syndromic microphthalmia [8], and mutations have been identified in retinoblastomas, rhabdomyosarcomas, AML as well as in CNS tumors including medulloblastomas and more recently in H3K27-mutated diffuse midline gliomas and anaplastic pleomorphic xanthoastrocytomas [3, 7, 10, 11, 13, 17].