AKT1 and cancer: In the first case, instrumental processes for MSC are the promotion of angiogenesis and contribution to the fibrovascular stromal network, mitigation of immune reactions, and stimulation of EMT and metastatic processes, while in the case where MSC exert a suppressive effect on the developing tumor, mechanisms such as cancer cell control, apoptosis induction, and regulation of Wnt and AKT signaling are involved and dominate.