Neuroblastoma Ras viral oncogene homologs (Nras, NRasV12), shP53, myr-AKT, c-Myc, ΔN90-β-catenin, c-Met and other oncogenes or viral genes have been used to establish HDI-based HCC models [6]. Here, AKT1 is linked to hepatocellular carcinoma.