SKP2 and hepatocellular carcinoma: Although it has been shown that Akt and N-Ras co-activation could rapidly increase proliferation and angiogenesis of HCC cells via mTORC1, FOXM1/SKP2, and c-Myc pathways [7], we still could not exclude that early recruitment of the macrophages into fatty change lesions of the Akt1/N-Ras-induced HCC contributes to the HCC progression.