Hypo-methylated CpGs in CF patients compared to controls included those associated with genes such as S100A14, LSP1, and OSCAR. S100A14 is a member of a S100 family of proteins, a family of calcium-binding cytosolic proteins composed of 25 known members that have a broad range of intracellular and extracellular functions including regulating calcium balance, cell apoptosis, migration, and proliferation [27, 28]. This evidence concerns the gene OSCAR and cystic fibrosis.